Skin Cancer Home > Yervoy Side Effects

People who are receiving Yervoy to treat melanoma skin cancer may develop reactions to this drug. Clinical studies have shown that some of the most commonly reported side effects of Yervoy include fatigue, itching, and diarrhea. Make sure you seek medical attention if you develop potentially serious problems, such as severe diarrhea, blurred vision, and fainting.

An Introduction to Yervoy Side Effects

Just like any medicine, Yervoy™ (ipilimumab) can cause side effects. However, not everyone who receives the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Yervoy. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Yervoy

Yervoy has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common Yervoy side effects included:
  • Fatigue -- in up to 41 percent of people
  • Diarrhea -- up to 32 percent
  • Itching -- up to 31 percent
  • Rash -- up to 29 percent.

Serious Side Effects

Some side effects of Yervoy are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Severe diarrhea
  • Black, tarry, or bloody stools
  • Abdominal (stomach) pain or bloating
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Tiredness or fatigue
    • Pain in the upper-right area of the abdomen (stomach)
  • Redness, blistering, or peeling of the skin
  • Sores in the mouth
  • Numbness, tingling, or weakness of the legs, arms, hands, or feet
  • Extreme tiredness, feeling cold all the time, or weight gain
  • Changes in mood
  • Feeling dizzy or faint
  • Eye or vision problems, such as:
    • Blurred vision
    • Double vision
    • Eye pain
    • Eye redness.
Some Yervoy side effects have been reported months after treatment ended. Therefore, make sure to tell your healthcare provider about potentially serious reactions that you may experience both during treatment and for several months after you stop receiving Yervoy.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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