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Sylatron Warnings and Precautions

Before you start using Sylatron, make sure your healthcare provider knows if you have liver disease, diabetes, or thyroid problems. Other important safety precautions with Sylatron involve warnings of potential allergic reactions and drug interactions. This medicine can also increase your risk for heart problems, eye damage, or depression.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Sylatron™ (peginterferon alfa-2b) if you have:
  • Depression or other mood disorders
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Thyroid problems
  • Diabetes
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Sylatron

Some warnings and precautions to be aware of prior to using this medicine include the following:
  • Interferon medications, including Sylatron, may increase the risk for depression (see Sylatron and Depression). Make sure your healthcare provider knows if you have depression or another mood disorder (such as bipolar disorder or manic depression) or if your depression seems to get worse while you are using Sylatron.
  • In studies, Sylatron appeared to increase the risk for heart problems, such as heart attacks or irregular heart rhythms (arrhythmias). If you develop heart problems, you will probably need to stop using this medication permanently.
  • Sylatron can damage the retina of the eyes, sometimes leading to blindness. Let your healthcare provider know immediately if you develop any vision changes, such as blurred vision.
  • This medicine can affect your liver. Check with your healthcare provider before using this medicine if you have liver disease of any kind.
  • Sylatron can affect thyroid function, sometimes unpredictably. It is recommended that your healthcare provider check your thyroid function using a simple blood test before you start this medication and periodically thereafter.
  • Based on experience with other similar medications, Sylatron might cause diabetes. Your healthcare provider may want to check you blood sugar periodically.
  • This product is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Sylatron and Pregnancy).
  • It is not known whether Sylatron passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Sylatron and Breastfeeding).
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Sylatron Medication Information

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