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Proleukin Warnings and Precautions

Specific Precautions and Warnings With Proleukin

Some warnings and precautions to be aware of prior to receiving this medication include the following:
  • Proleukin can cause damage to the heart, lungs, kidneys, liver, and central nervous system. Because of the risks associated with its use, this medication should only be given to people who have normal heart, lung, liver, and central nervous system function. Your healthcare provider will perform certain tests to make sure you are a candidate for Proleukin treatment.
  • This medication should only be used in a hospital with an intensive care unit, and only under the supervision of a healthcare provider with experience using medications to treat cancer.
  • Proleukin has been associated with a life-threatening condition known as capillary leak syndrome. This condition occurs when fluid from blood vessels leaks out into nearby body cavities and muscles, causing low blood pressure and potential damage to vital organs. You will be closely monitored for capillary leak syndrome during treatment.
  • You may have an increased risk for infection during Proleukin treatment, including potentially life-threatening infections of the blood and the lining of the heart. If you have a bacterial infection before starting Proleukin, the infection will need to be treated prior to receiving your first dose. Your healthcare team will monitor you for infections during treatment. You may be given antibiotics to help prevent an infection from occurring.
  • This medication can cause significant central nervous system effects, such as:
    • Severe drowsiness and fatigue
    • Confusion
    • Depression
    • Difficulty walking or talking
    • Agitation
    • Seizures
    • Coma.
Your healthcare provider will stop treatment if you develop any potentially serious central nervous system side effects. Let your healthcare provider know if you feel extremely drowsy during treatment.
  • Proleukin may cause or worsen autoimmune or inflammatory conditions. Make sure your healthcare provider knows if you have an autoimmune disease or inflammatory condition before beginning treatment.
  • You will be closely monitored every day you receive this medication to check for any potentially serious side effects. Monitoring will include vital signs, such as heart rate, blood pressure, and temperature; lab tests to check your blood cell counts; and liver, heart, and kidney function tests. If any of the tests are abnormal, your healthcare provider may recommend you skip a dose or stop treatment.
  • Proleukin is a pregnancy Category C medication, which means it may not be safe for use during pregnancy (see Proleukin and Pregnancy).
  • It is unknown whether Proleukin passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving the drug (see Proleukin and Breastfeeding).
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