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Proleukin Side Effects

Low blood pressure, decreased urination, and diarrhea were some of the most commonly reported reactions when Proleukin was given to people during clinical trials. Research also showed that side effects of Proleukin can occur frequently and be potentially dangerous. Contact your healthcare provider right away if you develop serious complications, such as fainting, chest pain, or unusual bleeding or bruising.

An Introduction to Proleukin Side Effects

Just like any chemotherapy medicine, Proleukin® (aldesleukin) can cause side effects, some of which can occur frequently and be quite significant. Talk to your healthcare provider about ways to prevent or manage adverse reactions.
(This article covers many, but not all, of the possible side effects with Proleukin. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Proleukin

Proleukin has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common Proleukin side effects included:
  • Low blood pressure (hypotension) -- in up to 71 percent of people
  • Diarrhea -- up to 67 percent
  • Decreased urination -- up to 63 percent
  • Chills -- up to 52 percent
  • Vomiting -- up to 50 percent
  • Shortness of breath -- up to 43 percent
  • Rash -- up to 42 percent
  • High bilirubin levels (which could be a sign of liver damage) -- up to 40 percent
  • Low blood platelets (which could increase the risk for bleeding) -- up to 37 percent
  • Nausea -- up to 35 percent
  • Confusion -- up to 34 percent
  • High blood creatine (which could be a sign of kidney damage) -- up to 33 percent.
Other common reactions, occurring in 10 percent to 29 percent of people, included:
  • Fever
  • Low red blood cells (anemia)
  • Swelling of the arms, hands, legs, ankles, feet, or other areas of the body
  • General feelings of discomfort
  • Weakness or lack of energy
  • Itching
  • Breathing problems
  • Fast heart rate
  • Increase in certain liver enzymes
  • Drowsiness
  • Mouth sores or inflammation
  • Decreased appetite
  • Peeling, flaking, and redness of the skin
  • Low white blood cells (which could increase the risk for infection)
  • Weight gain
  • Infection
  • General pain
  • Abdominal (stomach) pain
  • Enlarged abdomen (stomach)
  • Low blood levels of magnesium and calcium
  • Anxiety
  • Dizziness
  • Cough
  • Runny or stuffy nose.
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Proleukin Medication Information

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