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Proleukin Dosage

Your healthcare provider will determine your Proleukin dosage based on your weight and how well you tolerate the drug, among other factors. The medicine is given as an IV infusion by a healthcare provider. One course of treatment consists of an IV infusion given every eight hours for five days, followed by a nine-day break, and then an additional five days of treatment.

An Introduction to Dosing With Proleukin

The dose of Proleukin® (aldesleukin) your healthcare provider recommends may vary, depending on how you tolerate the medication. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Proleukin Dosage?

The standard recommended dose of Proleukin for the treatment of renal cell carcinoma (kidney cancer) and melanoma (skin cancer) is 0.37 mg per kg body weight (about 0.17 mg per lb) every eight hours for five days, or a maximum of 14 doses. After nine days without treatment, the dosing schedule will repeat for another five days for a maximum of 14 additional doses.
This five days of treatment, nine days of rest, and five additional days of treatment constitute one treatment course.
Your healthcare provider may recommend you skip a dose if you are experiencing potentially serious or intolerable Proleukin side effects. In clinical trials, doses were often withheld due to side effects, and many people were unable to tolerate an entire 28-dose course of treatment.
Your healthcare provider may recommend additional courses of treatment if your tumors have reduced in size and you did not experience dangerous side effects. Each treatment course should be separated by at least seven weeks.

General Information on Receiving Proleukin

Some considerations to keep in mind during treatment with Proleukin include the following:
  • This medication is given as a slow injection into a vein (an intravenous, or IV, infusion) every eight hours for five days, followed by a nine-day break, and then an additional five days of treatment.
  • The injection is normally administered by a healthcare provider in a healthcare setting, such as a hospital.
  • It takes 15 minutes to complete each Proleukin IV infusion.
  • Your healthcare provider may give you other medicines to help prevent or manage certain side effects.
  • Proleukin should be inspected before use, and should not be given if it contains particles or is discolored.
  • For the medication to work properly, it must be used as prescribed.
  • If you are unsure about anything related to your dosage or Proleukin dosing in general, please talk to your healthcare provider or pharmacist.
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Proleukin Medication Information

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