The exact causes of Merkel cell carcinoma are not known. However, researchers have learned that:
Merkel cell carcinoma can develop quickly in people who have had an organ transplant and are taking drugs to suppress their immune system (called immunosuppressives)
Exposure to arsenic may increase the risk of developing the disease
Exposure to sunlight may play a role in developing Merkel cell carcinoma, because the disease usually occurs on the face, head, and neck.