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Mekinist Drug Interactions

If you are about to begin treatment with Mekinist, your healthcare provider will need to know about all medications, supplements, and vitamins you are taking. A few products can potentially cause drug interactions with Mekinist, which can decrease the effectiveness of the medications. Some of the medications that may negatively interact with Mekinist include aripiprazole, axitinib, and saxagliptin.

 

An Overview of Interactions With Mekinist

Mekinist™ (trametinib) can potentially interact with a few other medications. Some of the medications that may lead to a drug interaction with Mekinist include but are not limited to:
   

Mekinist Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when any of the drugs mentioned above are combined with Mekinist.
 
Aripiprazole
Mekinist may decrease blood levels of aripiprazole, potentially making it less effective. Your healthcare provider may choose to adjust your aripiprazole dosage if you take these medicines together.
 
Axitinib
Mekinist may decrease blood levels of axitinib, potentially making it less effective. These medicines should generally not be taken together when at all possible. Your healthcare provider may choose to monitor you more closely if you do take them together.
 
Saxagliptin
Mekinist may decrease blood levels of saxagliptin, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take these medicines together. However, the manufacturer of saxagliptin does not recommend that saxagliptin doses be adjusted.
 
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