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Kidney damage, breathing problems, and low blood pressure are just some of the complications that may occur if Yervoy is combined with certain drugs. Interactions may also occur when it is combined with amphotericin B, digoxin, or warfarin. To help avoid these and other possible reactions, make sure your healthcare provider knows about all other medications, vitamins, and supplements you are taking.
An Overview of Interactions With YervoyYervoy™ (ipilimumab) may react with several other medications. Some of the drugs that may interact with Yervoy include but are not limited to:
- Amphotericin B (Abelcet®, AmBisome®, Amphotec®)
- Digoxin (Lanoxin®)
- Vemurafenib (Zelboraf®)
- Warfarin (Coumadin®, Jantoven®).
Yervoy Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Yervoy is combined with any of the drugs listed above.
Combining Yervoy with amphotericin B could increase your risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing difficulties due to constriction of the muscles around the airways (bronchospasm). Your healthcare provider may monitor you more closely for these problems if you use these medicines together.
Yervoy may decrease the amount of digoxin absorbed into the bloodstream, which could make digoxin less effective. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
In studies, some people taking both Yervoy and vemurafenib developed increased liver enzymes and sometimes increased bilirubin, which might be a sign of liver damage. Check with your doctor before combining these medications.