Solaraze Gel is licensed for the treatment of dry, scaly precancerous patches on the skin known as actinic keratoses. This prescription medication is a type of NSAID and works by blocking certain enzymes in the body and reducing inflammation. It comes in the form of a gel and is typically applied to the skin twice a day for 60 to 90 days. The most common side effects of this product are itching, rashes, and dry skin.
What Is Solaraze Gel?
Solaraze® Gel (diclofenac gel) is a prescription medication approved to treat actinic keratosis (AK). Actinic keratoses are dry, scaly precancerous patches on the skin.
Solaraze Gel is made by PharmaDerm, a division of Nycomed US, Inc.
How Does Solaraze Gel Work?
Diclofenac, the active ingredient in Solaraze Gel, belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). Like other NSAIDs, it works by blocking a specific enzyme known as cyclooxygenase (COX) and blocking the production of various inflammatory substances in the body.
It is not entirely clear why Solaraze works to treat actinic keratosis lesions. However, it is thought that by inhibiting the COX enzymes, Solaraze may encourage death of the precancerous cells.
This medication has been thoroughly evaluated in clinical studies. These studies compared Solaraze Gel to a placebo (a gel that does not contain any active ingredient). These studies demonstrated that Solaraze Gel was significantly better than the placebo for eliminating actinic keratoses.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Solaraze Gel [package insert]. Melville, NY: PharmDerm;2008 March.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed December 8, 2013.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed June 23, 2009.
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