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Proleukin Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Proleukin is combined with any of the drugs listed above.
 
Aminoglycoside Antibiotics
Combining Proleukin with aminoglycoside antibiotics could increase your risk for kidney damage. Your healthcare provider may choose to monitor your kidney function closely if you use these medicines together.
 
Blood Pressure Medications
Combining Proleukin with high blood pressure medications may lower your blood pressure to unsafe levels. If you take a blood pressure medicine during Proleukin treatment, your healthcare provider will monitor your blood pressure closely, and lower the dose of your high blood pressure medicine if needed.
 
Chemotherapy Medications
There have been reports of serious allergic reactions, including skin redness, itching, and low blood pressure, occurring in people receiving Proleukin in addition to high doses of chemotherapy medications. Your healthcare provider will monitor you closely if you are receiving multiple anticancer medications.
 
Clozapine
Using clozapine and Proleukin together may increase the risk for dangerously low white blood cells, increasing the risk for serious infections. Talk to your healthcare provider before using these medicines together. It is important, however, that you do not stop taking clozapine without first speaking with your healthcare provider.
 
Corticosteroids
Corticosteroids may reduce the effectiveness of Proleukin in reducing tumor size. Therefore, these medications should generally not be given together.
 
Doxorubicin
Combining Proleukin with doxorubicin may increase the risk for heart problems associated with both medications. Your healthcare provider will need to closely monitor you if you use these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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