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- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Kidney disease, such as kidney failure (renal failure)
- Heart disease
- Lung disease or problems breathing
- Any eye conditions or problems with vision
- High blood pressure (hypertension)
- Any allergies, including to foods, dyes, or preservatives.
- Pregnant or thinking of becoming pregnant (see Mekinist and Pregnancy)
- Breastfeeding (see Mekinist and Breastfeeding).