Hodgkin's lymphoma (also called Hodgkin's disease) is a cancer that begins in the lymphatic system, part of the body's immune system. It is an uncommon lymphoma, accounting for less than one percent of all cases of cancer in the United States. The other type of lymphoma, non-Hodgkin's lymphoma, is far more common (see Lymphoma Types for more information).
Hodgkin's lymphoma occurs when cells in the lymphatic system grow abnormally. The lymphatic system is made up of a network of vessels that carry a clear fluid called lymph throughout the body, much like blood vessels carry blood throughout the body. These lymph vessels connect the lymph nodes, which help trap and remove harmful substances that may be in the lymph. Other parts of the lymphatic system include the tonsils, spleen, bone marrow, and thymus.
Because lymph tissue is found throughout the body, lymphoma can begin in almost any part of the body. The abnormal lymphatic cells may spread beyond the lymph system to almost any tissue or organ in the body.
There are several different treatment options available for Hodgkin's disease. The specific treatment your healthcare provider recommends will depend on a variety of things, such as the type of Hodgkin's lymphoma you have, how far the cancer has spread, and your overall health (see Hodgkin's Disease Treatment).
DTIC-Dome is a type of chemotherapy treatment used to treat people with Hodgkin's lymphoma. It is approved as a second-line treatment, in combination with other medications. Second-line treatment is treatment that is used after other treatments have been tried without success. Therefore, DTIC-Dome will be tried when other treatment has not worked or has stopped working.