DTIC-Dome Drug Interactions
CYP 1A2 Inhibitor Medications
The liver breaks down DTIC-Dome using enzymes known as CYP 1A2 enzymes, and some medications known as CYP1A2 inhibitors can decrease the activity of these enzymes. Thus, combining DTIC-Dome with one of these drugs may increase the level of DTIC-Dome in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you use DTIC-Dome with a CYP 1A2 inhibitor.
Disulfiram may increase blood levels of DTIC-Dome, which could increase the chance of developing DTIC-Dome side effects. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
Echinacea may decrease the effectiveness of DTIC-Dome. Do not take echinacea during DTIC-Dome treatment without first speaking with your healthcare provider.
Isoniazid may increase the level of DTIC-Dome in your body, increasing your risk for side effects. Your healthcare provider may need to monitor you more closely if you use these medicines together.
Live vaccines are vaccines that contain live viruses or bacteria. People receiving chemotherapy, including DTIC-Dome, are generally advised to not receive live vaccines. Like other chemotherapy medicines, DTIC-Dome decreases your immune response. This means you could become infected with the virus or bacteria used to make a live vaccine. Also, live vaccines may be less effective while you are receiving DTIC-Dome. Talk to your healthcare provider before getting a vaccination during DTIC-Dome treatment.
Monoamine Oxidase Inhibitors (MAOIs)
Combining an MAOI with DTIC-Dome may increase your risk for a drop in blood pressure when getting up from a seated or lying position. This could cause you to faint or fall down. If you use these medicines together, try to sit or stand slowly, especially if you feel dizzy or faint.